The actress is in talks to feature as the wife of the iconic US president John F. Kennedy in the film by director Lee Daniels.
He has written a new screenplay called "The Butler", about a staffer Eugene Allen, who served in the White House for 34 years, waiting on eight different presidents from 1952, reports dailystar.co.uk.
Hugh Jackman, John Cusack and media mogul Oprah Winfrey have also been linked to the project.
If Kunis signs on, she will become the latest actress to portray Jackie Kennedy. Earlier, Katie Holmes played her in the History Channel mini-series "The Kennedys".