The Powerpuff Girls: Probably in the league of the biggest hits in cartoon shows was The Powerpuff Girls created by Craig McCracken. The story about three adorable little girls who have superpowers and fight the villains to save their city. Moreover with villains like Mojo Jojo, the show had to be a hit! For our good news, there is a fresh series of Powerpuff Girls under progress set for a 2016 release!